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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50331428
Substrate
n/a
Meas. Tech.
ChEMBL_687185 (CHEMBL1291810)
IC50
880±n/a nM
Citation
 Haffner, CD; Thomson, SA; Guo, Y; Schaller, LT; Boggs, S; Dickerson, S; Gobel, J; Gillie, D; Condreay, JP N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1. Bioorg Med Chem Lett 20:6983-8 (2010) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50331428
Synonyms:
3-Cyano-N-{3-[(1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-propyl}-benzamide | CHEMBL1289412
Type:
Small organic molecule
Emp. Form.:
C24H20N4O3S
Mol. Mass.:
444.506
SMILES:
O=C(NCCCN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1)c1cccc(c1)C#N |t:7|
Structure:
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