Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50331909
Substrate
n/a
Meas. Tech.
ChEMBL_687325 (CHEMBL1292001)
Ki
1926±n/a nM
Citation
 McGuinness, BF; Ho, KK; Stauffer, TM; Rokosz, LL; Mannava, N; Kultgen, SG; Saionz, K; Klon, A; Chen, W; Desai, H; Rogers, WL; Webb, M; Yin, J; Jiang, Y; Li, T; Yan, H; Jing, K; Zhang, S; Majumdar, KK; Srivastava, V; Saha, S Discovery of novel quinolinone adenosine A2B antagonists. Bioorg Med Chem Lett 20:7414-20 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50331909
Synonyms:
CHEMBL1290435 | N-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)-3-phenylpropanamide
Type:
Small organic molecule
Emp. Form.:
C30H27N3O2S
Mol. Mass.:
493.619
SMILES:
O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1
Structure:
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