Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50331909
Substrate
n/a
Meas. Tech.
ChEMBL_687323 (CHEMBL1291999)
Ki
>10000±n/a nM
Citation
 McGuinness, BF; Ho, KK; Stauffer, TM; Rokosz, LL; Mannava, N; Kultgen, SG; Saionz, K; Klon, A; Chen, W; Desai, H; Rogers, WL; Webb, M; Yin, J; Jiang, Y; Li, T; Yan, H; Jing, K; Zhang, S; Majumdar, KK; Srivastava, V; Saha, S Discovery of novel quinolinone adenosine A2B antagonists. Bioorg Med Chem Lett 20:7414-20 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50331909
Synonyms:
CHEMBL1290435 | N-((2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroquinolin-6-yl)methyl)-3-phenylpropanamide
Type:
Small organic molecule
Emp. Form.:
C30H27N3O2S
Mol. Mass.:
493.619
SMILES:
O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: