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Target
Cholesteryl ester transfer protein
Ligand
BDBM50334832
Substrate
n/a
Meas. Tech.
ChEMBL_699336 (CHEMBL1647254)
IC50
40±n/a nM
Citation
 Kallashi, F; Kim, D; Kowalchick, J; Park, YJ; Hunt, JA; Ali, A; Smith, CJ; Hammond, ML; Pivnichny, JV; Tong, X; Xu, SS; Anderson, MS; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Cumiskey, AM; Latham, M; Peterson, LB; Rosa, R; Sparrow, CP; Wright, SD; Sinclair, PJ 2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice. Bioorg Med Chem Lett 21:558-61 (2010) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50334832
Synonyms:
CHEMBL1643164 | ethyl 4-(4-(2-(4-(5-cyano-7-methylbenzo[d]oxazol-2-yl)phenylamino)-2-oxoethyl)piperazin-1-yl)benzoate
Type:
Small organic molecule
Emp. Form.:
C30H29N5O4
Mol. Mass.:
523.5824
SMILES:
CCOC(=O)c1ccc(cc1)N1CCN(CC(=O)Nc2ccc(cc2)-c2nc3cc(cc(C)c3o2)C#N)CC1
Structure:
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