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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50334861
Substrate
n/a
Meas. Tech.
ChEMBL_699552 (CHEMBL1647910)
IC50
100±n/a nM
Citation
 Labroli, M; Paruch, K; Dwyer, MP; Alvarez, C; Keertikar, K; Poker, C; Rossman, R; Duca, JS; Fischmann, TO; Madison, V; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Guzi, TJ Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2. Bioorg Med Chem Lett 21:471-4 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50334861
Synonyms:
7-amino-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile | CHEMBL1643215
Type:
Small organic molecule
Emp. Form.:
C16H18N8
Mol. Mass.:
322.3677
SMILES:
Cn1cc(cn1)-c1cnn2c(N)c(C#N)c(nc12)C1CCCNC1
Structure:
Search PDB for entries with ligand similarity: