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Target
Telomere resolvase ResT
Ligand
BDBM50335560
Substrate
n/a
Meas. Tech.
ChEMBL_713937 (CHEMBL1660353)
IC50
2730±n/a nM
Citation
 Lefas, G; Chaconas, G High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. Antimicrob Agents Chemother 53:4441-9 (2009) [PubMed]  Article 
Target
Name:
Telomere resolvase ResT
Synonyms:
REST_BORBU | resT
Type:
PROTEIN
Mol. Mass.:
54325.70
Organism:
Borrelia burgdorferi
Description:
ChEMBL_713937
Residue:
449
Sequence:
MPPKVKIKNDFEIFRKELEILYKKYLNNELSYLKLKEKLKILAENHKAILFRKDKFTNRSIILNLSKTRKIIKEYINLSVIERIRRDNTFLFFWKSRRIKELKNIGIKDRKKIEELIFSNQMNDEKSYFQYFIDLFVTPKWLNDYAHKYKIEKINSYRKEQIFVKINLNTYIEIIKLLLNQSRDIRLKFYGVLMAIGRRPVEVMKLSQFYIADKNHIRMEFIAKKRENNIVNEVVFPVFADPELIINSIKEIRYMEQTENLTKEIISSNLAYSYNRLFRQIFNNIFAPEESVYFCRAIYCKFSYLAFAPKNMEMNYWITKVLGHEPNDITTAFHYNRYVLDNLDDKADNSLLTLLNQRIYTYVRRKATYSTLTMDRLESLIKEHHIFDDNYIKTLIVIKNLMLKDNLETLAMVRGLNVKIRKAFKATYGYNYNYIKLTEYLSIIFNYKL
  
Inhibitor
Name:
BDBM50335560
Synonyms:
2,2'-(3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene-1,8-diyl)bis(5,7-dihydroxychroman-3,2-diyl)bis(3,4,5-trihydroxybenzoate) | CHEMBL1451483
Type:
Small organic molecule
Emp. Form.:
C43H32O20
Mol. Mass.:
868.7022
SMILES:
Oc1cc(O)c2CC(OC(=O)c3cc(O)c(O)c(O)c3)C(Oc2c1)c1cc(O)c(O)c2c1cc(cc(O)c2=O)C1Oc2cc(O)cc(O)c2CC1OC(=O)c1cc(O)c(O)c(O)c1
Structure:
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