Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50336000
Substrate
n/a
Meas. Tech.
ChEMBL_717059 (CHEMBL1671177)
Ki
4.4±n/a nM
Citation
Burch, JD; Farand, J; Colucci, J; Sturino, C; Ducharme, Y; Friesen, RW; Lévesque, JF; Gagné, S; Wrona, M; Therien, AG; Mathieu, MC; Denis, D; Vigneault, E; Xu, D; Clark, P; Rowland, S; Han, Y Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor. Bioorg Med Chem Lett 21:1041-6 (2011) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
Inhibitor
Name:
BDBM50336000
Synonyms:
2-(2-methoxyphenyl)-N-(3-methyl-4-(1-oxo-4,9-bis(2,2,2-trifluoroethoxy)-1H-benzo[f]isoindol-2(3H)-yl)phenethyl)acetamide | CHEMBL1669021
Type:
Small organic molecule
Emp. Form.:
C34H30F6N2O5
Mol. Mass.:
660.6028
SMILES:
COc1ccccc1CC(=O)NCCc1ccc(N2Cc3c(C2=O)c(OCC(F)(F)F)c2ccccc2c3OCC(F)(F)F)c(C)c1