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Target
Cathepsin K
Ligand
BDBM50336091
Substrate
n/a
Meas. Tech.
ChEMBL_718115 (CHEMBL1671568)
IC50
0.3±n/a nM
Citation
 Isabel, E; Mellon, C; Boyd, MJ; Chauret, N; Deschênes, D; Desmarais, S; Falgueyret, JP; Gauthier, JY; Khougaz, K; Lau, CK; Léger, S; Levorse, DA; Li, CS; Massé, F; Percival, MD; Roy, B; Scheigetz, J; Thérien, M; Truong, VL; Wesolowski, G; Young, RN; Zamboni, R; Black, WC Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. Bioorg Med Chem Lett 21:920-3 (2011) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50336091
Synonyms:
(S)-N-(cyanomethyl)-2-((S)-2,2-difluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)-4-methylpentanamide | CHEMBL1669438
Type:
Small organic molecule
Emp. Form.:
C23H27F2N3O3S
Mol. Mass.:
463.541
SMILES:
CC(C)C[C@H](N[C@H](C(F)F)c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(=O)NCC#N |r|
Structure:
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