Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50336688
Substrate
n/a
Meas. Tech.
ChEMBL_722948 (CHEMBL1674459)
IC50
8±n/a nM
Citation
Orcajo-Rincón, L; Ortega-Gutiérrez, S; Serrano, P; Torrecillas, IR; Wüthrich, K; Campillo, M; Pardo, L; Viso, A; Benhamú, B; López-Rodríguez, ML Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy. J Med Chem 54:1096-100 (2011) [PubMed] Article
More Info.:
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Inhibitor
Name:
BDBM50336688
Synonyms:
CHEMBL1672710 | N2-{[1-({(2R)-2-carboxymethyl-3-[4-phosphonomethyl)phenyl]propanoyl}amino)cyclohexyl]carbonyl}-N1-[3-(1-naphthyl)propyl]-L-aspartamide
Type:
Small organic molecule
Emp. Form.:
C36H44N3O10P
Mol. Mass.:
709.7224
SMILES:
OC(=O)C[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(O)=O)C(=O)NCCCc1cccc2ccccc12 |r|