Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50337223
Substrate
n/a
Meas. Tech.
ChEMBL_726362 (CHEMBL1687494)
IC50
64±n/a nM
Citation
 Shao, Y; Anilkumar, GN; Carroll, CD; Dong, G; Hall, JW; Hobbs, DW; Jiang, Y; Jenh, CH; Kim, SH; Kozlowski, JA; McGuinness, BF; Rosenblum, SB; Schulman, I; Shih, NY; Shu, Y; Wong, MK; Yu, W; Zawacki, LG; Zeng, Q II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists. Bioorg Med Chem Lett 21:1527-31 (2011) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50337223
Synonyms:
5-chloro-6-(4-(1-(4-chlorobenzyl)-3-methylpiperidin-4-yl)piperazin-1-yl)-N-methylnicotinamide | CHEMBL1681854
Type:
Small organic molecule
Emp. Form.:
C24H31Cl2N5O
Mol. Mass.:
476.442
SMILES:
CNC(=O)c1cnc(N2CCN(CC2)C2CCN(Cc3ccc(Cl)cc3)CC2C)c(Cl)c1
Structure:
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