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Target
Transcription factor Jun
Ligand
BDBM50340614
Substrate
n/a
Meas. Tech.
ChEMBL_739507 (CHEMBL1763333)
IC50
200±n/a nM
Citation
 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett 21:1719-23 (2011) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50340614
Synonyms:
CHEMBL1761569 | N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine
Type:
Small organic molecule
Emp. Form.:
C20H15N7S
Mol. Mass.:
385.445
SMILES:
Cc1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4nccs4)c3n2)cc1
Structure:
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