Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50340847
Substrate
n/a
Meas. Tech.
ChEMBL_739627 (CHEMBL1763453)
IC50
3945±n/a nM
Citation
Yoshikawa, K; Yoshino, T; Yokomizo, Y; Uoto, K; Naito, H; Kawakami, K; Mochizuki, A; Nagata, T; Suzuki, M; Kanno, H; Takemura, M; Ohta, T Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 21:2133-40 (2011) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50340847
Synonyms:
CHEMBL1761605 | N-(2-(5-chloro-N-methyl-1H-indole-2-carboxamido)ethyl)-N,5-dimethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H24ClN5O2S
Mol. Mass.:
445.966
SMILES:
CN(CCN(C)C(=O)c1nc2CCN(C)Cc2s1)C(=O)c1cc2cc(Cl)ccc2[nH]1