Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM50342285
Substrate
n/a
Meas. Tech.
ChEMBL_743865 (CHEMBL1767808)
IC50
3940±n/a nM
Citation
 Wempe, MF; Jutabha, P; Quade, B; Iwen, TJ; Frick, MM; Ross, IR; Rice, PJ; Anzai, N; Endou, H Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem 54:2701-13 (2011) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM50342285
Synonyms:
(2-Ethyl-7-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone | CHEMBL1767105
Type:
Small organic molecule
Emp. Form.:
C17H14O4
Mol. Mass.:
282.2907
SMILES:
CCc1cc2c(ccc(O)c2o1)C(=O)c1ccc(O)cc1
Structure:
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