Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50343444
Substrate
n/a
Meas. Tech.
ChEMBL_746174 (CHEMBL1775788)
EC50
0.6±n/a nM
Citation
 Semple, G; Ren, A; Fioravanti, B; Pereira, G; Calderon, I; Choi, K; Xiong, Y; Shin, YJ; Gharbaoui, T; Sage, CR; Morgan, M; Xing, C; Chu, ZL; Leonard, JN; Grottick, AJ; Al-Shamma, H; Liang, Y; Demarest, KT; Jones, RM Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett 21:3134-41 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50343444
Synonyms:
CHEMBL1773292 | tert-butyl 4-(9-(2-fluoro-4-(methylsulfonyl)phenyl)-8-oxo-8,9-dihydro-7H-purin-6-yloxy)piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H26FN5O6S
Mol. Mass.:
507.535
SMILES:
CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(-c3ccc(cc3F)S(C)(=O)=O)c(=O)[nH]c12 |(25.19,-11.96,;25.19,-13.5,;23.86,-14.27,;23.85,-12.72,;26.53,-14.27,;26.52,-15.81,;25.19,-16.58,;27.86,-16.58,;29.19,-15.81,;30.52,-16.58,;30.52,-18.12,;29.19,-18.9,;27.86,-18.12,;31.86,-18.88,;31.86,-20.42,;30.53,-21.19,;30.53,-22.74,;31.87,-23.51,;33.2,-22.74,;34.67,-23.22,;35.15,-24.68,;34.11,-25.82,;34.59,-27.29,;36.1,-27.61,;37.13,-26.45,;36.65,-24.99,;37.67,-23.85,;36.57,-29.07,;35.55,-30.22,;38.06,-28.66,;37.66,-30.15,;35.58,-21.96,;37.12,-21.96,;34.67,-20.71,;33.2,-21.19,)|
Structure:
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