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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50344510
Substrate
n/a
Meas. Tech.
ChEMBL_747848 (CHEMBL1781103)
EC50
15±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Greenlee, WJ; Jayne, C; Neustadt, B; Stamford, A; Vaccaro, H; Xu, XL; Baker, H; O'Neill, K; Woods, M; Hawes, B; Kowalski, T Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Bioorg Med Chem Lett 21:3290-6 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50344510
Synonyms:
4-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-3-fluorobenzonitrile | CHEMBL1778247
Type:
Small organic molecule
Emp. Form.:
C22H24FN5O3S
Mol. Mass.:
457.521
SMILES:
Cc1c(Nc2ccc(cc2F)C#N)ncnc1OC1C[C@@H]2CC[C@@H](C1)N2S(=O)(=O)C1CC1 |r,TLB:17:18:25:21.22|
Structure:
Search PDB for entries with ligand similarity: