Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50344514
Substrate
n/a
Meas. Tech.
ChEMBL_747848 (CHEMBL1781103)
EC50
1150±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Greenlee, WJ; Jayne, C; Neustadt, B; Stamford, A; Vaccaro, H; Xu, XL; Baker, H; O'Neill, K; Woods, M; Hawes, B; Kowalski, T Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Bioorg Med Chem Lett 21:3290-6 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50344514
Synonyms:
(1S,3S,5R)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octan-6-ol | CHEMBL1778252
Type:
Small organic molecule
Emp. Form.:
C21H26N4O5S
Mol. Mass.:
446.52
SMILES:
Cc1ncccc1Oc1ncnc(O[C@H]2C[C@@H]3CC(O)[C@@H](C2)N3S(=O)(=O)C2CC2)c1C |r,TLB:13:14:22:18.17,THB:19:18:22:14.21.15|
Structure:
Search PDB for entries with ligand similarity: