Target
Glycogen synthase kinase 3
Ligand
BDBM7266
Substrate
n/a
Meas. Tech.
ChEMBL_749959 (CHEMBL1786936)
IC50
>10000±n/a nM
Citation
 Power, DPLozach, OMeijer, LGrayson, DHConnon, SJ Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones. Bioorg Med Chem Lett 20:4940-4 (2010) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase 3
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51607.56
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_749959
Residue:
440
Sequence:
MKNWPIDEDINIYEEKNHTNNKNYVNNFEMSDQKDEEEYSHSSNRSEDEDEERTIDNEINRSPNKSYKLGNIIGNGSFGVVYEAICIDTSEQVAIKKVLQDPQYKNRELMIMKNLNHINIIYLKDYYYTESFKKNEKNIFLNVVMEYIPQTVHKYMKYYSRNNQALPMFLVKLYSYQLCRALSYIHSKFICHRDLKPQNLLIDPRTHTLKLCDFGSAKNLLAGQRSVSYICSRFYRAPELMLGSTNYTTHIDLWSLGCIIAEMILGYPIFSGQSSVDQLVRIIQVLGTPTEDQLKEMNPNYADIKFPDVKSKDLRKVFPKGTPDEAINLITQFLKYEPLKRLNPIEALADPFFDELRDPCIKLPKYIDKLPELFNFCKEEIQEMSMECRRKIIPKNVYEEFLMVDENDNNIINDTISNDFNESNLDTNNSNNKTHVIIES
  
Inhibitor
Name:
BDBM7266
Synonyms:
14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one | 9-bromopaullone | CHEMBL296586 | Kenpaullone | NSC 664704 | Paullone Analog 5 | cid_3820
Type:
Small organic molecule
Emp. Form.:
C16H11BrN2O
Mol. Mass.:
327.175
SMILES:
Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Structure:
Search PDB for entries with ligand similarity: