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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50346389
Substrate
n/a
Meas. Tech.
ChEMBL_750421 (CHEMBL1785973)
Ki
320±n/a nM
Citation
 Utech, T; Köhler, J; Wünsch, B Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA ands receptor antagonists. Eur J Med Chem 46:2157-69 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50346389
Synonyms:
(R)-N-benzyl-2-(2,2-diphenyl-1,3-dioxan-4-yl)ethanamine | CHEMBL1783454
Type:
Small organic molecule
Emp. Form.:
C25H27NO2
Mol. Mass.:
373.4874
SMILES:
C(C[C@@H]1CCOC(O1)(c1ccccc1)c1ccccc1)NCc1ccccc1 |r|
Structure:
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