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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50346394
Substrate
n/a
Meas. Tech.
ChEMBL_750421 (CHEMBL1785973)
Ki
1250±n/a nM
Citation
 Utech, T; Köhler, J; Wünsch, B Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA ands receptor antagonists. Eur J Med Chem 46:2157-69 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50346394
Synonyms:
CHEMBL1783459
Type:
Small organic molecule
Emp. Form.:
C15H25NO2
Mol. Mass.:
251.3645
SMILES:
NCC[C@@H]1CCOC2(O1)C1CC3CC(C1)CC2C3 |r,wU:3.2,TLB:14:13:17:10.9.7,14:9:12.13.15:17,THB:7:9:12:15.16.17,7:16:12:10.14.9,6:7:12.13.15:17,(-.27,-32.01,;-1.61,-31.24,;-2.94,-32.01,;-4.28,-31.24,;-4.28,-29.7,;-5.6,-28.92,;-6.93,-29.7,;-6.92,-31.25,;-5.6,-32,;-6.91,-32.79,;-8.31,-33.14,;-9.64,-32.65,;-10.84,-33.93,;-9.34,-33.5,;-7.93,-34.07,;-9.34,-31.91,;-8.3,-30.68,;-9.65,-31.16,)|
Structure:
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