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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50334175
Substrate
n/a
Meas. Tech.
ChEMBL_753266 (CHEMBL1799477)
IC50
70±n/a nM
Citation
 Ottanà, R; Maccari, R; Giglio, M; Del Corso, A; Cappiello, M; Mura, U; Cosconati, S; Marinelli, L; Novellino, E; Sartini, S; La Motta, C; Da Settimo, F Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications. Eur J Med Chem 46:2797-806 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50334175
Synonyms:
2-(2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3-yl)acetic acid | CHEMBL1645381
Type:
Small organic molecule
Emp. Form.:
C18H13NO5S
Mol. Mass.:
355.365
SMILES:
OC(=O)CN1C(=O)S\C(=C/c2ccc(Oc3ccccc3)cc2)C1=O
Structure:
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