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Target
Retinol-binding protein 4
Ligand
BDBM50092055
Substrate
n/a
Meas. Tech.
ChEMBL_756077 (CHEMBL1804187)
EC50
2372±n/a nM
Citation
 Campos-Sandoval, JA; Redondo, C; Kinsella, GK; Pal, A; Jones, G; Eyre, GS; Hirst, SC; Findlay, JB Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor. J Med Chem 54:4378-87 (2011) [PubMed]  Article 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM50092055
Synonyms:
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide | (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenamide | 3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid (4-hydroxy-phenyl)-amide | 4-hydroxyphenyl retinamide | CHEMBL7301 | FENRETINIDE | N-(4-HYDROXYPHENYL)ALL-TRANS RETINAMIDE | N-(4-hydroxyphenyl)-retinamide | N-(4-hydroxyphenyl)retinamide | N-(4-hydroxyphenyl)retinamide, 4-HPR
Type:
Small organic molecule
Emp. Form.:
C26H33NO2
Mol. Mass.:
391.5457
SMILES:
C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1 |c:4|
Structure:
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