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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50347952
Substrate
n/a
Meas. Tech.
ChEMBL_755938 (CHEMBL1803828)
IC50
8±n/a nM
Citation
 Wu, Y; Karna, S; Choi, CH; Tong, M; Tai, HH; Na, DH; Jang, CH; Cho, H Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors. J Med Chem 54:5260-4 (2011) [PubMed]  Article 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50347952
Synonyms:
CHEMBL1800139 | US8637558, 11
Type:
Small organic molecule
Emp. Form.:
C18H20ClNO3S
Mol. Mass.:
365.874
SMILES:
OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Cl)c1 |w:7.8,t:1|
Structure:
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