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Target
Macrophage migration inhibitory factor
Ligand
BDBM50349059
Substrate
n/a
Meas. Tech.
ChEMBL_759145 (CHEMBL1811202)
IC50
5600±n/a nM
Citation
 Jorgensen, WL; Trofimov, A; Du, X; Hare, AA; Leng, L; Bucala, R Benzisothiazolones as modulators of macrophage migration inhibitory factor. Bioorg Med Chem Lett 21:4545-9 (2011) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50349059
Synonyms:
CHEMBL1807931
Type:
Small organic molecule
Emp. Form.:
C13H6ClF2NOS
Mol. Mass.:
297.708
SMILES:
Fc1ccc2c(sn(-c3ccc(Cl)cc3)c2=O)c1F
Structure:
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