Reaction Details Report a problem with these data
Target
Peptide deformylase
Ligand
BDBM50349084
Substrate
n/a
Meas. Tech.
ChEMBL_759152 (CHEMBL1811209)
IC50
67000±n/a nM
Citation
 Antczak, C; Shum, D; Bassit, B; Frattini, MG; Li, Y; de Stanchina, E; Scheinberg, DA; Djaballah, H Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorg Med Chem Lett 21:4528-32 (2011) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
3.5.1.88 | BON69_24600 | BON94_18585 | D9G11_24945 | D9G11_25760 | D9J60_20755 | FORC82_p394 | PDF | Polypeptide deformylase | SAMEA3472033_04733 | def | def_2
Type:
n/a
Mol. Mass.:
16901.39
Organism:
Escherichia coli
Description:
n/a
Residue:
150
Sequence:
MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEKGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIGLRLGNGKYCTLRLFFNQV
  
Inhibitor
Name:
BDBM50349084
Synonyms:
CHEMBL1807952
Type:
Small organic molecule
Emp. Form.:
C17H10Cl2O6
Mol. Mass.:
381.164
SMILES:
COc1ccc(cc1OC)C(=O)c1coc2c1C(=O)C(=O)C(Cl)=C2Cl |c:24|
Structure:
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