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Target
Transmembrane protease serine 11D
Ligand
BDBM50349364
Substrate
n/a
Meas. Tech.
ChEMBL_760105 (CHEMBL1810428)
Ki
76±n/a nM
Citation
 Sielaff, F; Böttcher-Friebertshäuser, E; Meyer, D; Saupe, SM; Volk, IM; Garten, W; Steinmetzer, T Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett 21:4860-4 (2011) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 11D
Synonyms:
Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain
Type:
PROTEIN
Mol. Mass.:
46272.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_840134
Residue:
418
Sequence:
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
  
Inhibitor
Name:
BDBM50349364
Synonyms:
CHEMBL1809219
Type:
Small organic molecule
Emp. Form.:
C25H33N5O4S
Mol. Mass.:
499.626
SMILES:
CC(C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N |r|
Structure:
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