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Target
Carbonic anhydrase 14
Ligand
BDBM50153971
Substrate
n/a
Meas. Tech.
ChEMBL_760550 (CHEMBL1815535)
Ki
34.3±n/a nM
Citation
 Carta, F; Garaj, V; Maresca, A; Wagner, J; Avvaru, BS; Robbins, AH; Scozzafava, A; McKenna, R; Supuran, CT Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg Med Chem 19:3105-19 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 14
Synonyms:
CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:
Enzyme
Mol. Mass.:
37665.67
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme.
Residue:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
  
Inhibitor
Name:
BDBM50153971
Synonyms:
4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-benzenesulfonamide | 4-(4,6-dichloro-1,3,5-triazin-2-ylamino)benzenesulfonamide | CHEMBL366069
Type:
Small organic molecule
Emp. Form.:
C9H7Cl2N5O2S
Mol. Mass.:
320.155
SMILES:
NS(=O)(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Structure:
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