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Target
Carbonic anhydrase 2
Ligand
BDBM10867
Substrate
n/a
Meas. Tech.
ChEMBL_762737 (CHEMBL1815988)
pH
7.5±n/a
Ki
75.0±n/a nM
Comments
extracted
Citation
 Nishimori, I; Minakuchi, T; Vullo, D; Scozzafava, A; Supuran, CT Inhibition studies of theß-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates. Bioorg Med Chem 19:5023-30 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10867
Synonyms:
4-amino-6-chlorobenzene-1,3-disulfonamide | CHEMBL266240 | aromatic/heteroaromatic sulfonamide 12
Type:
Small organic molecule
Emp. Form.:
C6H8ClN3O4S2
Mol. Mass.:
285.728
SMILES:
Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O
Structure:
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