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Target
Mitogen-activated protein kinase 8
Ligand
BDBM15997
Substrate
n/a
Meas. Tech.
ChEMBL_763186 (CHEMBL1820097)
IC50
28±n/a nM
Citation
 Bamborough, P; Brown, MJ; Christopher, JA; Chung, CW; Mellor, GW Selectivity of kinase inhibitor fragments. J Med Chem 54:5131-43 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48297.57
Organism:
Homo sapiens (Human)
Description:
JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
  
Inhibitor
Name:
BDBM15997
Synonyms:
2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)benzoic acid | 4-anilinopyrimidine 8f
Type:
Small organic molecule
Emp. Form.:
C17H13FN4O2
Mol. Mass.:
324.3091
SMILES:
OC(=O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1
Structure:
Search PDB for entries with ligand similarity: