Target
Renin
Ligand
BDBM29949
Substrate
n/a
Meas. Tech.
ChEMBL_763606 (CHEMBL1820132)
IC50
0.5±n/a nM
Citation
 Yuan, JSimpson, RDZhao, WTice, CMXu, ZCacatian, SJia, LFlaherty, PTGuo, JIshchenko, AWu, ZMcKeever, BMScott, BBBukhtiyarov, YBerbaum, JPanemangalore, RBentley, RDoe, CPHarrison, RKMcGeehan, GMSingh, SBDillard, LWBaldwin, JJClaremon, DA Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket. Bioorg Med Chem Lett 21:4836-43 (2011) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM29949
Synonyms:
piperidine-1-carboxamide, 21l
Type:
Small organic molecule
Emp. Form.:
C28H46ClN3O3
Mol. Mass.:
508.136
SMILES:
[H][C@]1(CCCN(C1)C(=O)N[C@H](CNC)CC1CCCCC1)[C@@](O)(CCCCOC)c1cccc(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: