Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351373
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
170±n/a nM
Citation
 Saito, TObitsu, TKondo, TMatsui, TNagao, YKusumi, KMatsumura, NUeno, SKishi, AKatsumata, SKagamiishi, YNakai, HToda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351373
Synonyms:
CHEMBL1819063
Type:
Small organic molecule
Emp. Form.:
C22H29N5O
Mol. Mass.:
379.4986
SMILES:
CCC(CC)Nc1c2NCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(-1.6,-13.26,;-2.94,-14,;-2.97,-15.54,;-1.65,-16.34,;-.31,-15.59,;-4.32,-16.29,;-4.35,-17.83,;-5.7,-18.57,;-7.16,-18.07,;-8.09,-19.3,;-7.21,-20.56,;-5.73,-20.11,;-4.41,-20.91,;-3.05,-20.15,;-1.6,-20.65,;-.68,-19.41,;.86,-19.43,;-1.57,-18.16,;-3.03,-18.62,;-1.14,-22.12,;-2.18,-23.24,;-1.72,-24.71,;-.22,-25.05,;.24,-26.52,;-.8,-27.66,;.82,-23.91,;.36,-22.45,;1.4,-21.31,)|
Structure:
Search PDB for entries with ligand similarity: