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Target
Solute carrier family 5 member 4
Ligand
BDBM20875
Substrate
n/a
Meas. Tech.
ChEMBL_764617 (CHEMBL1821169)
IC50
16±n/a nM
Citation
 Ohtake, Y; Sato, T; Matsuoka, H; Nishimoto, M; Taka, N; Takano, K; Yamamoto, K; Ohmori, M; Higuchi, T; Murakata, M; Kobayashi, T; Morikawa, K; Shimma, N; Suzuki, M; Hagita, H; Ozawa, K; Yamaguchi, K; Kato, M; Ikeda, S 5a-Carba-ß-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem 19:5334-41 (2011) [PubMed]  Article 
Target
Name:
Solute carrier family 5 member 4
Synonyms:
Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 3 | SAAT1 | SC5A4_HUMAN | SGLT3 | SLC5A4 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4
Type:
PROTEIN
Mol. Mass.:
72452.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_764617
Residue:
659
Sequence:
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
  
Inhibitor
Name:
BDBM20875
Synonyms:
1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one | CHEMBL241384 | CHEMBL245067 | JMC511145 Compound 1 | O-glucoside, 1 | Phlorizin
Type:
Natural product
Emp. Form.:
C21H24O10
Mol. Mass.:
436.4093
SMILES:
OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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