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Target
Sterol regulatory element-binding protein 2
Ligand
BDBM93773
Substrate
n/a
Meas. Tech.
ChEMBL_765688 (CHEMBL1827133)
IC50
10700±n/a nM
Citation
 Kamisuki, S; Shirakawa, T; Kugimiya, A; Abu-Elheiga, L; Choo, HY; Yamada, K; Shimogawa, H; Wakil, SJ; Uesugi, M Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem 54:4923-7 (2011) [PubMed]  Article 
Target
Name:
Sterol regulatory element-binding protein 2
Synonyms:
BHLHD2 | SRBP2_HUMAN | SREBF2 | SREBP2
Type:
PROTEIN
Mol. Mass.:
123713.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_765690
Residue:
1141
Sequence:
MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS
  
Inhibitor
Name:
BDBM93773
Synonyms:
4-(4-chlorophenyl)-2-(2-propyl-4-pyridinyl)thiazole;hydrobromide | 4-(4-chlorophenyl)-2-(2-propyl-4-pyridyl)thiazole;hydrobromide | 4-(4-chlorophenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;hydrobromide | 4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-2-propyl-pyridine | CHEMBL1622565 | MLS000562232 | SMR000177579 | cid_2852359
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2S
Mol. Mass.:
314.832
SMILES:
CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: