Target
Sterol regulatory element-binding protein 2
Ligand
BDBM78179
Substrate
n/a
Meas. Tech.
ChEMBL_765690 (CHEMBL1827135)
IC50
10000±n/a nM
Citation
 Kamisuki, SShirakawa, TKugimiya, AAbu-Elheiga, LChoo, HYYamada, KShimogawa, HWakil, SJUesugi, M Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem 54:4923-7 (2011) [PubMed]  Article 
Target
Name:
Sterol regulatory element-binding protein 2
Synonyms:
BHLHD2 | SRBP2_HUMAN | SREBF2 | SREBP2
Type:
PROTEIN
Mol. Mass.:
123713.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_765690
Residue:
1141
Sequence:
MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS
  
Inhibitor
Name:
BDBM78179
Synonyms:
2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 2-Propyl-4-(4-p-tolyl-thiazol-2-yl)-pyridine | 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;hydrobromide | CHEMBL1621019 | MLS000332366 | SMR000221636 | cid_2850562
Type:
Small organic molecule
Emp. Form.:
C18H18N2S
Mol. Mass.:
294.414
SMILES:
CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: