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Target
Transcriptional regulator ERG
Ligand
BDBM50352421
Substrate
n/a
Meas. Tech.
ChEBML_766760
IC50
12000±n/a nM
Citation
 Ontoria, JM; Bufi, LL; Torrisi, C; Bresciani, A; Giomini, C; Rowley, M; Serafini, S; Bin, H; Hao, W; Steinkühler, C; Jones, P Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors. Bioorg Med Chem Lett 21:5274-82 (2011) [PubMed]  Article 
Target
Name:
Transcriptional regulator ERG
Synonyms:
ERG | ERG_HUMAN | Transforming protein ERG
Type:
PROTEIN
Mol. Mass.:
54615.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1335569
Residue:
486
Sequence:
MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
  
Inhibitor
Name:
BDBM50352421
Synonyms:
CHEMBL1823591
Type:
Small organic molecule
Emp. Form.:
C22H19ClN6O2
Mol. Mass.:
434.878
SMILES:
Clc1ccccc1NC(=O)N1CCN(CC1)c1nc(no1)-c1ccc2ccccc2n1
Structure:
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