Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50353632
Substrate
n/a
Meas. Tech.
ChEMBL_769810 (CHEMBL1831674)
IC50
5.8±n/a nM
Citation
 Ballatore, C; Soper, JH; Piscitelli, F; James, M; Huang, L; Atasoylu, O; Huryn, DM; Trojanowski, JQ; Lee, VM; Brunden, KR; Smith, AB Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. J Med Chem 54:6969-83 (2011) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
TA2R_MOUSE | Tbxa2r | Thromboxane A2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37114.77
Organism:
MOUSE
Description:
Thromboxane A2 TBXA2R MOUSE::P30987
Residue:
341
Sequence:
MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
  
Inhibitor
Name:
BDBM50353632
Synonyms:
CHEMBL1829812
Type:
Small organic molecule
Emp. Form.:
C24H28ClNO4S
Mol. Mass.:
462.001
SMILES:
OC1CC(Cc2cccc(CCNS(=O)(=O)c3ccc(Cl)cc3)c2)C(=O)C1CC1CC1
Structure:
Search PDB for entries with ligand similarity: