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Target
Cathepsin B
Ligand
BDBM50354245
Substrate
n/a
Meas. Tech.
ChEMBL_770721 (CHEMBL1837245)
Ki
3300±n/a nM
Citation
 Sosic, I; Mirkovic, B; Turk, S; Šefaneb, B; Kos, J; Gobec, S Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B. Eur J Med Chem 46:4648-56 (2011) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50354245
Synonyms:
CHEMBL1836519
Type:
Small organic molecule
Emp. Form.:
C17H21N3OS2
Mol. Mass.:
347.498
SMILES:
O=c1nc(SCC2CCCCC2)nc(SCc2ccccc2)[nH]1
Structure:
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