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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50355968
Substrate
n/a
Meas. Tech.
ChEMBL_776055 (CHEMBL1912525)
IC50
170±n/a nM
Citation
 Nishiguchi, GA; Atallah, G; Bellamacina, C; Burger, MT; Ding, Y; Feucht, PH; Garcia, PD; Han, W; Klivansky, L; Lindvall, M Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg Med Chem Lett 21:6366-9 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50355968
Synonyms:
CHEMBL1910899
Type:
Small organic molecule
Emp. Form.:
C21H21N7
Mol. Mass.:
371.4383
SMILES:
Nc1cc(ccn1)-c1ccc2c(n[nH]c2n1)-c1ccc(cc1)N1CCNCC1
Structure:
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