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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50356470
Substrate
n/a
Meas. Tech.
ChEMBL_775797 (CHEMBL1912300)
Ki
150±n/a nM
Citation
 Kombo, DC; Mazurov, A; Tallapragada, K; Hammond, PS; Chewning, J; Hauser, TA; Vasquez-Valdivieso, M; Yohannes, D; Talley, TT; Taylor, P; Caldwell, WS Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. Eur J Med Chem 46:5625-35 (2011) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50356470
Synonyms:
CHEMBL1911858
Type:
Small organic molecule
Emp. Form.:
C15H19N3O2
Mol. Mass.:
273.3303
SMILES:
O=C1CC(=NCC2(CN3CCC2CC3)N1)c1ccco1 |c:3,(-1.44,-20.48,;-1.12,-21.98,;.38,-22.34,;1.02,-23.74,;.34,-25.13,;-1.18,-25.45,;-2.37,-24.47,;-2.37,-26.01,;-3.7,-26.77,;-5.03,-26.01,;-5.03,-24.47,;-3.7,-23.69,;-2.95,-25.02,;-4.29,-25.78,;-2.35,-22.93,;2.57,-23.76,;3.49,-22.53,;4.95,-23.02,;4.92,-24.56,;3.45,-25.02,)|
Structure:
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