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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50356471
Substrate
n/a
Meas. Tech.
ChEMBL_775797 (CHEMBL1912300)
Ki
7.2±n/a nM
Citation
 Kombo, DC; Mazurov, A; Tallapragada, K; Hammond, PS; Chewning, J; Hauser, TA; Vasquez-Valdivieso, M; Yohannes, D; Talley, TT; Taylor, P; Caldwell, WS Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. Eur J Med Chem 46:5625-35 (2011) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50356471
Synonyms:
CHEMBL1911861
Type:
Small organic molecule
Emp. Form.:
C17H19N3O2
Mol. Mass.:
297.3517
SMILES:
Oc1c(oc2ccccc12)C1=NC2(CN1)CN1CCC2CC1 |t:12,(1.48,-2.66,;1.8,-1.16,;.78,-.01,;1.55,1.32,;3.06,1,;4.3,1.89,;5.7,1.27,;5.86,-.27,;4.61,-1.17,;3.21,-.53,;-.76,-.17,;-1.78,.98,;-3.19,.36,;-3.03,-1.17,;-1.53,-1.5,;-4.53,-.41,;-5.86,.36,;-5.86,1.89,;-4.52,2.66,;-3.18,1.9,;-3.96,.58,;-5.29,1.36,)|
Structure:
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