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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50357894
Substrate
n/a
Meas. Tech.
ChEMBL_787640 (CHEMBL1918093)
IC50
90±n/a nM
Citation
 Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem 54:7899-910 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50357894
Synonyms:
CHEMBL1916351
Type:
Small organic molecule
Emp. Form.:
C21H14F2N2O2
Mol. Mass.:
364.3449
SMILES:
Cc1cc(O)ccc1-c1[n+]([O-])ccc2c(ccnc12)-c1ccc(F)cc1F |(22.05,-38.39,;23.39,-39.16,;23.39,-40.7,;24.73,-41.47,;24.73,-43.01,;26.06,-40.69,;26.05,-39.15,;24.72,-38.39,;24.72,-36.86,;23.38,-36.09,;22.05,-36.85,;23.39,-34.54,;24.71,-33.77,;26.05,-34.53,;27.38,-33.76,;28.72,-34.54,;28.72,-36.08,;27.38,-36.85,;26.05,-36.08,;27.38,-32.23,;26.05,-31.46,;26.05,-29.93,;27.39,-29.15,;27.38,-27.61,;28.72,-29.92,;28.72,-31.46,;30.05,-32.23,)|
Structure:
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