Reaction Details Report a problem with these data
Target
Galanin receptor type 2
Ligand
BDBM50358662
Substrate
n/a
Meas. Tech.
ChEMBL_789439 (CHEMBL1924415)
IC50
560±n/a nM
Citation
 Sagi, VN; Liu, T; Lu, X; Bartfai, T; Roberts, E Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2. Bioorg Med Chem Lett 21:7210-5 (2011) [PubMed]  Article 
Target
Name:
Galanin receptor type 2
Synonyms:
GALNR2 | GALR2 | GALR2_HUMAN | Galanin R2 | Galanin receptor 2 | Galanin receptor type 2 | Galanin receptor type 2 (GAL2-R) (GALR2).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.40
Organism:
Homo sapiens (Human)
Description:
Galanin R2 GALR2 HUMAN::O43603
Residue:
387
Sequence:
MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
  
Inhibitor
Name:
BDBM50358662
Synonyms:
CHEMBL1922003
Type:
Small organic molecule
Emp. Form.:
C27H31F4N7
Mol. Mass.:
529.5756
SMILES:
Cc1c(F)cccc1Nc1cc(nc(n1)N1CCCN(CC1)c1ncccc1C(F)(F)F)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: