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Target
Protoporphyrinogen oxidase, mitochondrial
Ligand
BDBM50359942
Substrate
n/a
Meas. Tech.
ChEMBL_791251 (CHEMBL1929738)
Ki
70±n/a nM
Citation
 Zuo, Y; Yang, SG; Jiang, LL; Hao, GF; Wang, ZF; Wu, QY; Xi, Z; Yang, GF Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors. Bioorg Med Chem 20:296-304 (2011) [PubMed]  Article 
Target
Name:
Protoporphyrinogen oxidase, mitochondrial
Synonyms:
PPO II | PPOM_TOBAC | PPOX2 | PPX II | PPXII | PX-2 | Protoporphyrinogen IX oxidase isozyme II
Type:
PROTEIN
Mol. Mass.:
55416.61
Organism:
Nicotiana tabacum
Description:
ChEMBL_791251
Residue:
504
Sequence:
MAPSAGEDKHSSAKRVAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSVSQDGLIWDEGANTMTESEGDVTFLIDSLGLREKQQFPLSQNKRYIARNGTPVLLPSNPIDLIKSNFLSTGSKLQMLLEPILWKNKKLSQVSDSHESVSGFFQRHFGKEVVDYLIDPFVAGTCGGDPDSLSMHHSFPELWNLEKRFGSVILGAIRSKLSPKNEKKQGPPKTSANKKRQRGSFSFLGGMQTLTDAICKDLREDELRLNSRVLELSCSCTEDSAIDSWSIISASPHKRQSEEESFDAVIMTAPLCDVKSMKIAKRGNPFLLNFIPEVDYVPLSVVITTFKRENVKYPLEGFGVLVPSKEQQHGLKTLGTLFSSMMFPDRAPNNVYLYTTFVGGSRNRELAKASRTELKEIVTSDLKQLLGAEGEPTYVNHLYWSKAFPLYGHNYDSVLDAIDKMEKNLPGLFYAGNHRGGLSVGKALSSGCNAADLVISYLESVSTDSKRHC
  
Inhibitor
Name:
BDBM50359942
Synonyms:
ACIFLUORFEN
Type:
Small organic molecule
Emp. Form.:
C14H7ClF3NO5
Mol. Mass.:
361.657
SMILES:
OC(=O)c1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1[N+]([O-])=O
Structure:
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