Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor
Ligand
BDBM50360668
Substrate
n/a
Meas. Tech.
ChEMBL_795750 (CHEMBL1936379)
IC50
3±n/a nM
Citation
 Wang, Y; Fu, Z; Schmitt, M; Wang, X; Shen, W; Rickel, E; Martin, T; Budelsky, A; Marshall, D; Collins, T; Tang, HL; Medina, JC; Liu, JJ Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. Bioorg Med Chem Lett 22:367-70 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50360668
Synonyms:
CHEMBL1933763
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2F2N2O7S
Mol. Mass.:
617.446
SMILES:
CCCCNC(=O)c1ccc(Oc2ccc(cc2OC)C(F)(F)C(O)=O)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Structure:
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