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Target
Matrilysin
Ligand
BDBM50360969
Substrate
n/a
Meas. Tech.
ChEMBL_796148 (CHEMBL1937512)
IC50
57700±n/a nM
Citation
 Wu, Y; Li, J; Wu, J; Morgan, P; Xu, X; Rancati, F; Vallese, S; Raveglia, L; Hotchandani, R; Fuller, N; Bard, J; Cunningham, K; Fish, S; Krykbaev, R; Tam, S; Goldman, SJ; Williams, C; Mansour, TS; Saiah, E; Sypek, J; Li, W Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett 22:138-43 (2011) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50360969
Synonyms:
CHEMBL1935291
Type:
Small organic molecule
Emp. Form.:
C20H18N2O5S2
Mol. Mass.:
430.497
SMILES:
CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1nccs1)C(O)=O |r|
Structure:
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