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Target
Natural resistance-associated macrophage protein 2
Ligand
BDBM50361124
Substrate
n/a
Meas. Tech.
ChEMBL_795244 (CHEMBL1936903)
IC50
260±n/a nM
Citation
 Cadieux, JA; Zhang, Z; Mattice, M; Brownlie-Cutts, A; Fu, J; Ratkay, LG; Kwan, R; Thompson, J; Sanghara, J; Zhong, J; Goldberg, YP Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett 22:90-5 (2011) [PubMed]  Article 
Target
Name:
Natural resistance-associated macrophage protein 2
Synonyms:
DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2
Type:
PROTEIN
Mol. Mass.:
62262.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795244
Residue:
568
Sequence:
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTCHLGLTAQPELYLLNTMDADSLVSR
  
Inhibitor
Name:
BDBM50361124
Synonyms:
CHEMBL1933600
Type:
Small organic molecule
Emp. Form.:
C17H15FN4O3
Mol. Mass.:
342.3244
SMILES:
COc1ccc(NC(=O)c2c(C)[nH]n(-c3ccccn3)c2=O)cc1F
Structure:
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