Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50364418
Substrate
n/a
Meas. Tech.
ChEMBL_805403 (CHEMBL1955296)
EC50
>2500±n/a nM
Citation
 Reed, AB; Lanman, BA; Neira, S; Harrington, PE; Sham, KK; Frohn, M; Pickrell, AJ; Tasker, AS; Gore, A; Fiorino, M; Itano, A; McElvain, M; Middleton, S; Morrison, H; Xu, H; Xu, Y; Wong, M; Cee, VJ Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups. Bioorg Med Chem Lett 22:1779-83 (2012) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50364418
Synonyms:
CHEMBL1950560
Type:
Small organic molecule
Emp. Form.:
C24H22FN3S
Mol. Mass.:
403.515
SMILES:
NCCCc1ccc(-c2nc3ccc(nc3s2)C2(CC2)c2ccccc2)c(F)c1
Structure:
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