Reaction Details Report a problem with these data
Target
Kynurenine--oxoglutarate transaminase 1
Ligand
BDBM50364917
Substrate
n/a
Meas. Tech.
ChEMBL_804058 (CHEMBL1952453)
IC50
666000±n/a nM
Citation
 Akladios, FN; Nadvi, NA; Park, J; Hanrahan, JR; Kapoor, V; Gorrell, MD; Church, WB Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorg Med Chem Lett 22:1579-81 (2012) [PubMed]  Article 
Target
Name:
Kynurenine--oxoglutarate transaminase 1
Synonyms:
CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1
Type:
Aminotransferase; Lyase
Mol. Mass.:
47874.00
Organism:
Homo sapiens (Human)
Description:
Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:
422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
  
Inhibitor
Name:
BDBM50364917
Synonyms:
CHEMBL1950316
Type:
Small organic molecule
Emp. Form.:
C12H10N2O6
Mol. Mass.:
278.2176
SMILES:
OC(=O)CCc1c([nH]c2ccc(cc12)[N+]([O-])=O)C(O)=O
Structure:
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