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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50365099
Substrate
n/a
Meas. Tech.
ChEMBL_804894 (CHEMBL1953942)
IC50
2620±n/a nM
Citation
 Rydzik, AM; Kulis, M; Lukaszewicz, M; Kowalska, J; Zuberek, J; Darzynkiewicz, ZM; Darzynkiewicz, E; Jemielity, J Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety--fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis. Bioorg Med Chem 20:1699-710 (2012) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | IF4E_RABIT
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50365099
Synonyms:
CHEMBL1951197
Type:
Small organic molecule
Emp. Form.:
C21H27N11O20P4
Mol. Mass.:
877.398
SMILES:
C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)NP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12 |r|
Structure:
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