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Target
Renin
Ligand
BDBM50365566
Substrate
n/a
Meas. Tech.
ChEMBL_808017 (CHEMBL1961076)
IC50
28.2±n/a nM
Citation
 Lacombe, P; Arbour, M; Aspiotis, R; Cauchon, E; Chen, A; Dubé, D; Falgueyret, JP; Fournier, PA; Gallant, M; Grimm, E; Han, Y; Juteau, H; Liu, S; Mellon, C; Ramtohul, Y; Simard, D; St-Jacques, R; Tsui, GC 3,4-Diarylpiperidines as potent renin inhibitors. Bioorg Med Chem Lett 22:1953-7 (2012) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50365566
Synonyms:
CHEMBL1957793
Type:
Small organic molecule
Emp. Form.:
C28H32ClN3O3
Mol. Mass.:
494.025
SMILES:
CCOC(=O)NCCc1ccccc1-c1ccc([C@H]2CNCC[C@@H]2c2ccn(C)c(=O)c2)c(Cl)c1 |r|
Structure:
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