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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50171898
Substrate
n/a
Meas. Tech.
ChEMBL_805973 (CHEMBL1960409)
EC50
500±n/a nM
Citation
 Fracchiolla, G; Laghezza, A; Piemontese, L; Parente, M; Lavecchia, A; Pochetti, G; Montanari, R; Di Giovanni, C; Carbonara, G; Tortorella, P; Novellino, E; Loiodice, F Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists. Bioorg Med Chem 20:2141-51 (2012) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50171898
Synonyms:
(S)-3-Phenyl-2-(4-trifluoromethyl-phenoxy)-propionic acid | CHEMBL192518
Type:
Small organic molecule
Emp. Form.:
C16H13F3O3
Mol. Mass.:
310.2678
SMILES:
OC(=O)[C@H](Cc1ccccc1)Oc1ccc(cc1)C(F)(F)F
Structure:
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